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Yıl:2013; Cilt: 50; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2013;50(2):183-185
Psikotik Bir Ergen Hastada Olanzapine Bağlı Tardif Diskinezi ve Klozapin ile Tedavisi
AE Tufan, R Bilici, GK Uğurlu, S Yılmaz, A Erdoğan
Abant İzzet Baysal Üniversitesi, Bolu
Güncel klinik yaklaşımda çocuk ve ergenlerdeki çeşitli psikopatolojilerin tedavisi için atipik antipsikotiklere giderek artan bir sıklıkla başvurulmaktadır. Atipik antipsikotiklerin bu yaş grubunda yaygın olarak kullanımı, tardiv diskinezi (TD) gibi hareket bozukluklarını da içeren çeşitli sonuçlara yol açabilir. Bu çalışmada Orta Derecede Mental Retardasyon ve Farklılaşmamış Şizofreni tanılarıyla takip edilen bir ergen hastada uzun süreli olanzapin kullanımı sonrasında ortaya çıkan TD’nin tanısı ve klozapinle başarılı bir şekilde tedavisinin bildirilmesi amaçlanmıştır. Süreğen hastalığı, uzun süreli antipsikotik kullanımı, afektif ve negatif semptomları, mental retardasyonu ve diş enfeksiyonları olan kız ergen hastaların tardif diskinezi riski açısından belirli aralıklarla değerlendirilmesi gerektiği önerilebilir. Klozapin ergen hastalarda gelişen tardif diskinezinin tedavisinde bir seçenek olabilir. Atipik antipsikotiklerin çocuk ve ergenlerde çeşitli endikasyonlarla uzun sürelerle kullanımının giderek yaygınlaştığı göz önüne alındığında, bu hastalardaki TD’nin görünümü, tanısı ve tedavi yöntemleri hakkında ileri araştırmaların gerektiği düşünülebilir. (
Tardive Dyskinesia Due to Olanzapine in an Adolescent with Psychosis and its Treatment with Clozapine
Atypical antipsychotics are increasingly being used in the current clinical approach for the treatment of various psychopathologies in children and adolescents. The common use of atypical antipsychotics in this age group may lead to various consequences, including movement disorders, such as tardive dyskinesia (TD). In this study, we aimed to present the diagnosis of TD due to long-term use of olanzapine and successful treatment with clozapine in an adolescent patient who has been followed with the diagnoses of moderate mental retardation and undifferentiated schizophrenia. It may be posited that female adolescents with chronic illnesses, receiving long-term antipsychotic medication, with affective and negative symptoms, mental retardation, and teeth infections should be monitored regularly for TD. Clozapine may be a choice in the treatment of tardive dyskinesia developing in adolescent patients. Considering the increase in long-term use of atypical antipsychotics in children and adolescents for various indications, it can be though that further studies on the phenomenology, diagnosis and methods of treatment of TD in those patients are required.

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