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Yıl:2013; Cilt: 14; Sayı: 4>> Özet
TAM METİN
Anadolu Psikiyatri Dergisi; 2013;14(4):318-324
Psödonöbeti olan kadınlarda vestibüler uyarılmış miyojenik potansiyeller
BH Almiş, BE Cumurcu, AC Özcan, S Ünal
Adıyaman Üniversitesi, Adıyaman
Amaç: Bu çalışmada konversiyon bozukluğu alt tipi olan psödonöbetli hastalarda vestibüler uyarılmış miyojenik potansiyeller (vestibular evoked myogenic potentials-VEMP) uygulaması ile alt beyin sapı etkilenimini değerlendirmeyi amaçladık. Yöntem: Çalışmada, SCID-I/CV’e göre katılmalar veya konvülsiyonlar gösteren konversiyon bozukluğu tanısı konan 22 kadın ve 22 sağlıklı kadın değerlendirmeye alındı. Araştırmaya katılan hasta ve sağlıklı kontrollere deneyimli uzman bir araştırıcı tarafından SCID-I/CV uygulanmasının ardından, sosyodemografik veri formu, Hamilton Depresyon Değerlendirme Ölçeği ve Hamilton Anksiyete Değerlendirme Ölçeği uygulandı. Hasta ve sağlıklı kontrol grubunda VEMP değerlendirmesi nöroloji laboratuvarında yapıldı. Sonuçlar: Psödonöbetli hastaların VEMP değerlendirmelerinde P1 latansı sağda ve solda, sağlıklı kontrol grubu ile kıyaslandığında istatistiksel olarak anlamlı fark yoktu. Benzer şekilde psödonöbetli hastaların N1 latans değerleri sağda ve solda, sağlıklı kontrol grubu değerleri ile kıyaslandığında aradaki fark istatistiksel olarak anlamlı değildi. Psödonöbetli hastaların P1-N1 amplitüd değerleri, sağda ve solda kontrol grubu değerleri ile kıyaslandığında yine istatistiksel olarak anlamlı bir fark yoktu. Tartışma: Psödonöbetli hastalarda alt beyin sapının etkilenmesine yönelik yaptığımız VEMP çalışmasında psödonöbetli hastalarda VEMP değerlerinde sağlıklı kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı bir fark yoktu. Bu sonuç konversiyon bozukluğunda afferent uyaranların kortikofugal inhibisyonu olduğuna ilişkin hipotezle uyumlu görünmekle birlikte, VEMP dalgalarının P1-N1 (inhibitör bileşen) ve N23-P44 (eksitatör bileşen) bileşenlerinin ele alındığı bir algoritmle hesaplanmasıyla açıklık kazanabilecek gibi görünmektedir. Dekonvolüsyon yönteminin kullanıldığı ve konversiyon bozukluğunun diğer alt tiplerinin de ele alındığı daha geniş bir hasta grubunda çalışmanın yinelenmesi planlanabilir.
Vestibular evoked myogenic potentials at the women with pseudoseizure
Objective: We aimed to assess vulnerability in the lower brain stem at the patients with the pseudoseizure subtype of conversion disorder by vestibular evoked myogenic potentials (VEMP) in this study. Methods: In the study, 22 women with the diagnosis of conversion disorder which show convulsions according to SCID-I/CV and 22 healthy women are taken to assessment. After administration of SCID-I/CV by an experienced investigator to the patients and healthy controls, the sociodemographic data form, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were administered. VEMP evaluation performed at the patients and healthy control groups in a neurology laboratory. Results: P1 latency is no statistically significant difference at the patients with pseudoseizure compared to healthy control groups in the VEMP assessment at the right and left. Similarly, N1 latency values are no statistically significant difference between the patient and control groups. Right and left P1-N1 amplitude values no statistically significant difference at the patients with pseudoseizure compared to control groups values. Discussion: VEMP values no statistically significant difference at the patient compared to control groups at this study which it aimed to assess lower brain stem at the patients with the pseudoseizure subtype of conversion disorder by VEMP. This result is well adjusted hypothesis of increased corticofugal inhibition of afferent stimuli. However If P1-N1 (inhibition component) and N23-P44 (exitation component) components of VEMP waves to being careful, this subject will clear up. This study can plan again at the widely patients groups with deconvolution method and include other subtype of conversion disorder.

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