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Yıl:2013; Cilt: 24; Sayı: 4>> Özet
Türk Psikiyatri Dergisi; 2013;24(4):248-252
İnaktif Hepatit B Taşıyıcıları ve Kronik Hepatit B HastalarınınDepresyon ve Anksiyete Düzeylerinin Karşılaştırılması
NA Demir, M Çelik, S Kölgelier, Ş Sümer, S Aksöz, LS Demir, AÇ İnkaya
Adıyaman Devlet Hastanesi, Adıyaman
Amaç: Bu çalışmada, HBsAg pozitif inaktif taşıyıcı ve kronik hepatit hastalarından oluşan toplam 444 kişinin Hamilton depresyon ve anksiyete puanları karşılaştırılarak, kronik bir hastalığa sahip olmanın getirdiği psikolojik etkilerle hastalığın oluşturduğu fiziksel etkilerin hastaların ruhsal durumu üzerindeki bağıl katkılarının değerlendirilmesi amaçlandı. Yöntem: Bu çalışma, Adıyaman Devlet Hastanesi ve Adıyaman 82. Yıl Devlet Hastanesi Enfeksiyon Hastalıkları Polikliniği’nde takip edilen HBsAg pozitif 249 inaktif taşıyıcı (T), 195 kronik hepatit hastası (KHB) olmak üzere toplam 444 kişi üzerinde yapıldı. HBV taşıyıcılığı ve kronik hepatit B, Avrupa Karaciğer Çalışmaları Birliği (European Association for the Study of Liver/ EASL) kılavuzu eşliğinde teşhis edildi. Psikiyatrik görüşme ile tüm katılımcılara Hamilton Depresyon ve Hamilton Anksiyete Ölçekleri uygulandı. Bulgular: Katılımcıların Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ) puan ortalaması 6,2±8, Hamilton Anksiyete Değerlendirme Ölçeği (HADÖ) puan ortalaması 6,0±7,1 idi. HDDÖ puan ortalaması inaktif taşıyıcılarda 7,5±5,8, hastalarda 8,8±6,6 idi. Kronik hepatit B hastalarında HDDÖ puan ortalaması, inaktif taşıyıcılardan anlamlı olarak yüksekti (p=0,037). HADÖ puanı iki grupta benzerdi (p>0,05). Hastaların cinsiyetine ve yaşına göre anksiyete ve depresyon puanları açısından fark saptanmadı (p>0,05). Hastalığın süresi, ailede hepatit ve siroz öyküsü ile anksiyete ya da depresyon puanları arasında ilişki bulunmadı (p>0,05). Hem hasta hem taşıyıcılarda ek hastalık olması durumunda anksiyete puanları anlamlı olarak yüksek tespit edildi (p değeri sırasıyla 0,005 ve 0,001). Depresyon puanı ise ek hastalığı olan taşıyıcılarda anlamlı olarak yüksek bulundu (p=0,003). Sonuç: Kronik hepatitli hastaların tedavi ve izlemi sırasında anksiyete ve depresyon başta olmak üzere psikiyatrik ek tanılar önemli sorunlardır. Kronik hepatit varlığı ve eşlik eden başka hastalık bulunması psikiyatrik komplikasyon riskini artırmaktadır.
Comparison of the Level of Depression and Anxiety in Inactive Hepatitis B Carriers and Chronic Hepatitis B Patients
Objective: The aim of this study was to evaluate the relative contribution of chronic illness and the physical effects such illness on the mental status of chronic hepatitis B patients by comparing them to inactive hepatitis B carriers, based on Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) scores. Materials and Methods: The study included 444 participants: 249 HBsAg-positive inactive carriers (IC group) and 195 chronic hepatitis B patients (CH group) that were undergoing follow-up at Adiyaman University Research and Education Hospital, Department of Infectious Diseases Department. HBV carrier status and chronic hepatitis B were diagnosed based on European Association for the Study of Liver (EASL) guidelines. The HDRS and HARS were administered to all the participants via psychiatric interview. Results: The overall mean HDRS score was 6.2 ± 8 and the overall mean HARS score was 6.0 ± 7.1. Mean HDRS score in the IC group was 7.5 ± 5.8, versus 8.8 ± 6.6 in the CH group; the difference was significant (P = 0.037). Mean HARS score were similar in both groups (P > 0.05). There wasn’t a difference in anxiety or depression scores based on participants’gender or age (P > 0.05). Additionally, there wasn’t a correlation between duration of illness, and family history of hepatitis or cirrhosis, or anxiety or depression scores (P > 0.05). Anxiety scores were higher among the participants with comorbidity, in both CHB and IC groups (P= 0.005 and P = 0.001, respectively). Depression scores were higher among the IC group participants with comorbidity (P= 0.003). that can occur during the treatment and follow-up of chronic hepatitis patients. The presence of comorbidity in chronic hepatitis patients increases the risk of psychiatric complications. Conclusion: Psychiatric comorbidity, particularly anxiety and depression, are important problems

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