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Yıl:2012; Cilt: 5; Sayı: 3>> Özet
Türkiye Klinikleri Psikiyatri Özel Dergisi; 2012;5(3):49-58
Obsesif Kompulsif Bozuklukta Eşzamanlı Duygudurum Bozuklukları Tanısı: Yöntemsel Sorunlar ve Etiyopatogenez
Z Kökrek, G Sevinçer, N Konuk
İstanbul Sabahattin Zaim Üniversitesi, İnsan ve Toplum Bilimleri Fakültesi
Obsesif Kompulsif Bozukluk (OKB) ve Duygudurum Bozuklukları komorbiditesi ile ilgili epidemiyolojik veriler ve klinik gözlemler hangi bozukluğun klinik tabloyu belirlediğinin izahı bakımından yetersizdir. Her iki bozukluğun bir arada bulunduğu tablolar, tek tek bulundukları duruma göre tanısal ve klinik özellikleri, seyir biçimi, tedaviye cevapları ve prognoz bakımından farklılaşmaktadır. Psikiyatride komorbidite kavramı üzerinde uzlaşının bulunmaması bu konuda yapılan pek çok araştırmaya rağmen bu araştırmalardan nozolojik, etiyolojik ya da prognostik açıdan sonuç çıkarmanın önünde bir engel olarak durmaktadır. Bu derleme yazısında psikiyatride komorbidite kavramının tartışmalı bir örneği olarak “OKB ve Duygudurum Bozukluklarının birlikte görünümü” üzerine yapılan araştırmalar gözden geçirilmiştir. Komorbidite ile ilgili kavramsal tartışmanın ardından primer bozukluk grubu OKB olarak belirlenmiş duygudurum bozuklukları komorbiditesi araştırmaları, yöntemsel sorunları ve etiyopatogenezi açıklamaya muhtemel katkısı bakımından özetlenmiştir.
Comorbidity of Mood Disorders in Obsessive Compulsive Disorder: Special Emphasize on Methodologic Issues and Etiopathogenesis
Epidemiological data and clinical observations about the comorbidity of Obsessive compulsive disorder (OCD) and mood disorders are not enough today to explain which disorder primarily determines the clinical picture. The comorbid conditions differ from either conditions alone in terms of diagnostic and clinical aspects, disease course, response to the treatment and their prognosis. Lack of a consensus on the comorbidity concept of psychiatry hinders drawing nosological, etiological, and prognostic conclusions despite many studies on this topic. In this paper, comorbidity of OCD and mood disorders, as a contraversial example for concept of comorbidity, has been reviewed in the light of current literature. After discussing the conceptual aspects of comorbidity, the researches that identified OCD as the primary psychiatric condition and investigated comorbidity of mood disorders has been reviewed in terms of their methodological problems and possible contributions to explain etiopathogenesis as well.

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