Dergi Ara >>
Yıl:2012; Cilt: 49; Sayı: 2>> Özet
TAM METİN
Nöropsikiyatri Arşivi; 2012;49(2):108-113
Manyetik Rezonans Görüntüleme Kontrastlı FLAIR ile Kontrastlı T1 Sekanslarının Leptomeningeal Hastalık Değerlendirilmesi Yönünden Kıyaslanması: Hangisi Daha Etkin?
S Tepe
Bayındır Hastanesi, İstanbul
Amaç: Bu çalışmanın amacı kontrastlı T1 ağırlıklı MR görüntüleme ile kontrastlı FLAIR sekanslarını leptomeningeal karsinomatosis değerlendirilmesi yönünden karsılaştırmaktır. Yöntem: Tüm hastalarda T1 ve T2 ağırlıklı aksiyal ve koronal kontrastsız, spin eko, FLAIR aksiyal kontrastsız sekanslarını da içerecek şekilde rutin beyin görüntüleme sekansları ve yanı sıra, kontrastlı FLAIR ve T1 ağırlıklı sekanslar kullanıldı. Bu sekanslar 12 çalışma grubu hastasında (5 erkek, 7 kadın, yaş aralığı 51-82; 4 meme kanseri, 4 akciğer kanseri, 2 melanom, 2 lenfoma) uygulandı, hepsinde leptomeningeal karsinomatosis kanıtlanmıştı. Kıyaslamalar özellikle kontrastlı T1 ve kontrastlı FLAIR görüntüleri ile yapıldı. Bulgular: Klinik olarak leptomeningeal hastalığı kanıtlanmış 12 hastanın hepsinde (10'u metastatik karsinoma, 2'si lenfoma) kontrastlı FLAIR kesitlerinin, kontrastlı T1 kesitlerine göre patolojiyi daha iyi gösterdiği, daha bariz ve dikkat çekici kontrast tutulumu görüldüğü saptandı. Sonuç: Kontrastlı FLAIR görüntüler leptomeningeal hastalığı saptamada kontrastlı T1 sekansa kıyasla daha anlamlı bulundu.
Contrast-enhanced FLAIR Versus Contrast-enhanced T1-Weighted Sequence of Magnetic Resonance Imaging for the Evaluation of Leptomeningeal Disease: Which one is Better?
Objectives: The purpose of this study was to compare the sensitivity of gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI) and gadolinium-enhanced FLAIR (fluid attenuated inversion recovery) MRI in detecting leptomeningeal carcinomatosis. Method: In all patients, all routine brain imaging sequences were performed, including T1- and T2-weighted axial and coronal unenhanced spin-echo sequences, FLAIR axial unenhanced sequence, as well as contrast-enhanced FLAIR, and T1-weighted sequences. These sequences were used in the study group consisted of 12 patients (5 male, 7 female, age range: 51-82; 4 breast carcinoma, 4 lung carcinoma, 2 melanoma, 2 lymphoma) with proven leptomeningeal carcinomatosis disease. Comparisons were made particularly between enhanced T1- and FLAIR- enhanced images. Results: In all 12 patients with clinically proven leptomeningeal disease (10 metastatic carcinoma, 2 lymphoma), contrast-enhanced FLAIR sequence demonstrated better and more extensive and conspicuous enhancement when compared to contrast-enhanced T1 sequence. Discussion: Gadolinium-enhanced FLAIR images were superior to gadolinium-enhanced T1 sequences for detecting pathologic leptomeninges.

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