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Yıl:2011; Cilt: 1; Sayı: 4>> Özet
TAM METİN
Journal of Mood Disorders; 2011;1(4):145-151
Obsesif kompülsif bozukluğu olan ve olmayan iki uçlu bozukluk hastalarının klinik ve sosyo-demograifk özelliklerinin karşılaştırılması
A Hedayati, A Javadpour, A Bazrafshan, A Mani, A Azizi
Research center for Psychiatry and Behavioral Science, Shiraz University of Medical Sciences, Shiraz, Iran
Amaç: Epidemiyolojik çalışmalar iki uçlu bozukluğu olan hastalarda obsesif kompülsif bozukluğun hayat boyu yaygınlığının %3.2 ile %35 arasında olduğunu göstermektedir. Bu arada iki uçlu bozukluğun obsesif kompülsif bozukluk ile birlikte olduğu (İUB-OKB) ve olmadığı (saf İUB) hastalarla yapılan ve hastaların demografik ve klinik özelliklerini değerlendiren birkaç çalışmanın yayınlanan sonuçları tartışmalıdır. Bu çalışmanın amacı iki uçlu bozukluk hastalarından OKB ekhastalığı olan ve olmayanların sosyodemografik ve klinik özelliklerini karşılaştırmaktır.

Yöntem: DSM-IV Eksen I Bozuklukları için Yapılandırılmış Psikiyatrik Görüşme Formu (SCID-I) ile tanı konmuş 204 yatan hastanın katıldığı kesitsel, basit yapılı hastane kaynaklı bir çalışmadır. Demografik ve klinik değişkenler Yale-Brown obsesyon kompulsiyon ölçeği, Bech-Rafaelsen mania ölçeği ve Hamilton depresyon ölçeğinden elde edildi.

Bulgular: İki uçlu bozukluğu (İUB) olan 204 hastadan saf İUB’si olan 123 (%60.3) ve İUB-OKB’si olanlar ise 81 (%39.7) idi. İUB-OKB ve saf İUB grupları arasında eğitim (p=0.036) ve medeni durumlarında (p=0.022) önemli farklılıklar vardı. Gruplar karşılaştırıldığında klinik özelliklerden: intihar düşüncesi, yatkınlığı ve girişimleri (p=0.000); başvuru sıklığı (p=0.044); madde kötüye kullanım öyküsü (p=0.001), ailede OKB öyküsü (p=0.000); ailede duygudurum bozukluğu öyküsü (p=0.036) önemli farklılıklar göstermekteydi.

Sonuç: İUB ve OKB ekhastalığının belirgin demografik ve klinik özelliklerinin olması tanısal ve tedavi açısından farklı yaklaşımlara ihtiyacı olabilecek özel bir iki uçlu bozukluk tipi olabileceği izlenimini uyandırmaktadır. İlerideki çalışmalar bu alandaki bilgilerimizi artırmamıza yardımcı olabilir.
Comparison of socio-demographic and clinical features of bipolar patients with and without obsessive compulsive disorder
Objective: Recent epidemiological studies have shown that lifetime prevalence of obsessive compulsive disorder (OCD) in bipolar patients range from 3.2% to 35%. Meanwhile, few studies have evaluated demographic and clinical features of bipolar disorder (BD) with OCD (BD-OCD) and BD without OCD (pure BD), and the published results of such studies have been controversial. The aim of the current study was to compare the socio-demographic and clinical characteristics of BD patients with and without OCD

Methods: In a cross-sectional, simple convenient hospital-based study, 204 bipolar inpatients diagnosed based on Structured Clinical Interview for DSM-IV (SCID) were recruited. Demographic and clinical variables were obtained by using the Yale-Brown obsessive compulsive scale, Bech-Rafaelsen Mania Scale, and Hamilton Depression scale.

Results: Out of 204 patients with BD, 123 (60.3%) patients had pure BD and 81 (39.7%) had BD-OCD. There were significant differences between BD-OCD and pure BD group in terms of education (p=0.036) and marital status (p=0.022). Of clinical features, suicidal thoughts, tendencies, and attempts (p=0.000), frequency of admission (p=0.044), history of substance abuse (p=0.001), family history of OCD (p=0.000), and family history of mood disorder (p=0.036) were significantly different between the groups.

Conclusions: Distinct demographic and clinical characteristics of bipolar patients with OCD comorbidity suggest a specific type of bipolar mood disorder which might need a different diagnostic and therapeutic management. Further longitudinal studies may assist in enhancing our knowledge in this field.

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