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Yıl:2011; Cilt: 21; Sayı: 1>> Özet
TAM METİN
Klinik Psikofarmakoloji Bülteni; 2011;21(1):70-72
Metoklopramid kullanımına bağlı gelişen akut distoni olgusu
NC Uluğ, M Uluğ
Özel Ümit Hastanesi, Eskişehir
Metoklopramid, dopamin reseptör antagonisti olup, antiemetik olarak sık kullanılan bir ilaçtır. En önemli yan etkileri, acil tedavi gerektiren tardif diskinezi, parkinsonizm, akatizi, malign nöroleptik sendrom ve akut distonik reaksiyon gibi ekstrapiramidal semptomların varlığıdır. Çocuklarda insidansı %0,5?1 iken, adolesan ve yaşlılarda %25 civarındadır. Hastalar menenjit, ensefalit, hipokalsemi, nöbet ve tetanoz şeklinde yanlış tanı alabilmektedir. Bu raporda, acil polikliniğine uygun dozda metoklopramid kullanmakta iken akut distonik reaksiyon gelişmesi nedeniyle başvuran 24 yaşındaki bir bayan hasta sunulmuştur
A case report of acute dystonia caused by a therapeutic dose of metoclopramide
Metoclopramide is a dopamine receptor antagonist, frequently used as an antiemetic drug. Side effects include extrapyramidal reactions such as tardive dyskinesia, Parkinsonism, akathisia, neuroleptic malignant syndrome, and acute dystonic reaction requiring acute intervention. While the incidence of acute dystonic reaction is 0.5-1% in children, it is 25% in young adults and elderly. Patients can be misdiagnosed with meningitis, encephalitis, hypocalcaemia, seizures, and tetanus. In this report, a 24- [year]-old woman with acute dystonia precipitated by a therapeutic dose of metoclopramide, is presented.

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