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Yıl:2004; Cilt: 17; Sayı: 3>> Özet
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Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi; 2004;17(3):182-186
Akut Paraneoplastik Polinöropati: Olgu Sunumu
G Çelik, G Yüksel, A Akpınar, H Tireli
Paraneoplastik nöropatiler, malinitelere bağlı veya birlikte ortaya çıkan, ender olmakla beraber kanser hastalarının yaklaşık % 4-5'inde görülen klinik tablolardır. Genellikle subakut veya kronik başlangıçlıdır ve nonspesifik duysal semptomlar ön plandadır. En sık küçük hücreli akciğer kanseri, daha ender olarak da diğer organ malignitelerine sekonder olabilir. Jinekolojik organ maligniteleri ile birlikteliği ise oldukça enderdir.
Burada, akut başlayıp, hızlı progresyon gösteren paraparezi kliniği ile başvuran, EMG'sinde aksonal tutulumun ön planda olduğu sensorimotor polinöropati saptanan ve yapılan ileri tetkikleri ile endometrium kanseri tespit edilen bir olgu sunulmuştur. Akut polinöropatilerin etyolojisinde paraneoplastik sendromların da göz önünde bulundurularak bu yönde ayrıntılı inceleme yapılmasının erken tanı ve tedavi açısından önemine dikkat çekilmiştir.
Acute Paraneoplasti Polyneuropathy: Case Report
Paraneoplastic neuropathies are cancer related neuropathies which can be seen in 4-5 % of cancer patients. The presentation is usually with subacute or chronic nonspesific sensorial symptoms. They are most commonly seen in small cell lung cancer, and gynecologic malignancy related paraneoplastic polyneuropathies are extremely rare.
We present a 70 [year] old woman clinically presenting with an acute progressive paraparesis. Her electromyographic examination was suggestive of an sensorimotor axonal polyneuropathy. After her systemic evaluation, she was diagnosed with endometrial cancer and no other explanation for her polyneuropathy was found. We point out that paraneoplastic neuropathies must be included in the differential diagnosis of acute polyneuropathy syndromes which may help the early diagnosis and treatment of the underlying cancer.

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