Dergi Ara >>
Yıl:1984; Cilt: 1; Sayı: 1>> Özet
Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi; 1984;1(1):7-12
Elektrokonvulsif Tedavinin ATPAaz aktivitesi üzerine etkisi
N Alpay, M Ünal, T İspir
Bakırköy Ruh ve Sinir Hastalıkları Hastanesi
Elektokonvülsif tedavinin (EKT) eritrosit Na+-K+/Mg++' Ca++/Mg++ ve Mg++ ATP'az üzerine etkisini araştırmak amacıyla son bir yıl içinde EKT almamış ve şimdiki hastalığı nedeniyle EKT'ye uygun görülen 30 hasta ve kontrol grubu olarak 20 sağlıklı kişi çalışma kapsamına alınmıştır.

Hasta grubundan EKT'ye başlamadan önce l.kan (heparinli tüpe 10 cc), atropin yapıldıktan yarım saat sonra 2.kan, ilk EKT yapıldıktan 10. sonra 3.kan, son EKT den bir gün sonra aynı yöntemle 4.kan alınmıştır. Kontrol grubundan 1 kez kan alınmıştır. Tüplere yalnız protokol numaraları konmuştur.

ATP'az değerleri ile ilgili olarak da değişkenler arası karşılaştırmalar ve istatistiksel çözümleme yapılmıştır. Anlamlı bulunan sonuçlar şöyle özetlenebilir:

1-Hasta grubundan eritrosit ATP'az değerleri düşük bulunmuştur.

2- EKT öncesi yapılan atropinden yarım saat sonra alınan kanlarda Na*+K+/Mg++' ve Mg** ATP'az da artma Ca*VMg** ATP'az da düşme gözlenmiştir.

3- İlk EKT'den 10.dak sonra alınan kan Na+ -K/Mg**', Ca/Mg** ve Mg ATP'az değerlerinde yükselme görülmüştür.

4- EKT'ler tamamlandıktan bir gün sonra alınan kanda Na+ - K+/Mg+ Ca/Mg** ATP'azlarda artış, Mg++ ATP'azlarda düşme olmuştur.

Bu bulgular bu konuda yapılan başka çalışmalarda karşılaştırılarak tartışılmaktadır.

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