Dergi Ara >>
Yıl:2004; Cilt: 5; Sayı: 3>> Özet
TAM METİN
Bağımlılık Dergisi; 2004;5(3):139-146
Alkol kullanım bozukluklarında yeni bir biyokimyasal belirleyici: Carbonhydrate Deficient Transferrin (CDT)
CB Şengül, C Şengül, N Dilbaz, T Okay
Ankara Numune Hast. 2. Psikiyatri Kliniği, Ankara
Alkol kullanım bozukluğu; bireyin fiziksel, ruhsal sağlığını, aile, toplumsal ve iş uyumunu bozacak derecede sık ve fazla alkol alma, alkol alma isteğine karşı gelememe ile belirli, yaşam boyu yaygınlığı 7,9% (erkekler için 13,53%, kadınlar için 2,82% ) olan ciddi bir bozukluktur. Beraberinde ek tıbbi ve ruhsal bozukluklar doğuran alkol kullanım bozukluklarının saptanması, tanınması, tedavi edilmesi ve gerek relaps gerekse bağımlılığın önlenmesi için nesnel, özgüllüğü ve duyarlılığı yüksek, kolay uygulanabilir, güvenilir, uygun maliyetli biyolojik belirleyicilere gereksinim yaratmaktadır. Araştırmacılar bu amaçla her geçen gün yeni belirleyiciler üzerinde çalışılmalarını sürdürmektedirler. Carbohydrate Deficient Transferrin (CDT) Food and Drug Administration (FDA) tarafından onaylanmış ve geleneksel olanlardan daha özgül ve duyarlı olan bir belirleyicidir. CDT ilk kez 1976 yılında Stibler ve Kjellin tarafından bildirilmiştir. O günden günümüze CDT ile ilgili çok sayıda yayın yapılmıştır. Biz bu yazıda özellikle ülkemiz için oldukça yeni bir belirleyici olan CDT’yi daha yakından incelemeyi amaçladık. Bu amaçla Pubmed veri tabanını kullanarak CDT’nin ilk kez bildirildiği 1976’dan günümüze kadar olan literatürde CDT, belirleyici, alkol, transferrin gibi anahtar kelimeler kullanıldığında elde edilen ve tam metin olarak ulaşılan makaleler gözden geçirilmiştir.
A New Biomarker in Alcohol Use Disorders: Carbohydrate Deficient Transferrin (CDT)
Alcoholism is a serious disorder, which has a prevalence of 13.53% for men, 2.82% for women and 7.9% overall, was characterized by inability to resist desire for alcohol, excessive and frequent alcohol intake, which can disrupt individual’s physical and mental health and also family, work and social adaptation. Objective, sensitive, specific, reliable, economic, easily applicable biological markers are needed for diagnosis, treatment planning and prevention of relapse in alcoholism which can cause many alcohol related physical and mental disorders. Because of this, researchers are going on working for new biomarkers. Carbohydrate Deficient Transferrin (CDT) is new biomarker which is more specific and sensitive than traditional markers and approved by Food and Drug Administration (FDA). It was first reported by Stibler and Kjellin in 1976. Since than many researches were made on CDT and many articles were published on its usage in alcoholism. We investigated Pubmed data base by using key words alcohol, CDT, biomarker and transferrin in the literature published since 1976. And than we used the full text articles we managed to obtain to review literature on Carbohydrate Deficient Transferrin.

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