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Yıl:1992; Cilt: 29; Sayı: 2>> Özet
Nöropsikiyatri Arşivi; 1992;29(2):71-82
Kronik Şizofrenide Depressif Duygudurumu
N Motavallı
İ.Ü. Istanbul Tıp Faktültesi Çocuk Psikiyatrisi Anabilim dalı
1991 yılı Ağustos ayında Bakırköy Ruh ve Sinir Hastalıktan Hastanesinde yapılan bir çalışmada kronik şizofrenide depresif duygu durumu incelendi.
Çalışmaya kronik şizofreni tanısı ile yatmakta olan, ayrıca DSM-III-R ölçütlerine göre de aynı tanıyı alan 60 hasta alındı. Hastaların yarısı (30) depresif duygu durumu olan, yansı (30) depresif duygu durumu olmayan hastalardı. Depresif duygu durumunun farmakojenik, postpsikotik, akinetik depresyon ve negatif belirtilerle ilişkisini saptamak amacıyla her iki gruba Hamilton depresyon ölçeği, negatif belirleri değerlendirme ölçeği, pozitif belirtileri değerlendirme ölçeği ve ekstrapiramidal belirtileri değerlendirme ölçeğinin parkinsonizme ait bölümü uygulandı. İki alt gruba ait istatistikler Ki-kare, t-testi, lineer korelasyon kullanılarak değerlendirildi. İki grup arasmda antipsikoük ve antikolinerjik ilaç miktan, pozitif psikotik belirtiler, akinezi şiddeti açısından anlamlı fark bulunmadı. Depresif duygu durumu olmayan grupta duygusal küntlük anlamlı oranda yüksek bulundu. Aynca depresif duygu durumu ile duygusal düzlük arasmda ters orantı saptandı. Dürtüsüzlük, enerjisizlik, vurdumduymazlık ve haz almama gibi negatif belirtilerin depresif grupta daha fazla olduğu görüldü. Depresif duygu durumu olan grupta psişik anksiyete, intihar düşüncesi ve Hamilton toplam puanı anlamlı oranda yüksek bulundu. Aynca bu gruptaki Hamilton toplam puanının ortalaması eşiğin üzerinde saptandı. Sonuçlar, çeşitli yayınlarda bildirilen sonuçlarla karşılaştırılarak tartışıldı.
Depressive Mood in Chronic Schizophrenia
In this study, done in Agust 1991 in Bakirköy State Hospital of Mental Disorders, depressive mood in chronic schizophrenic patients is evaluated, 60 in patients diagnosed as chronic schizophrenia and reevaluated according to DSM-III-R criteria were included in this study. After initial interview the patients were divided into two groups. Those who have depressive mood and those who haven't. In order to consider the relationship between depressive mood and negative symptoms, pharmacogenic depression, postpsychotic depression and akinetic depression, Hamilton scale for depression, scale for assesment of the negative symptoms, scale for assesment of positive symptoms and scale for assesment of extrapyramidal symptoms concerning parkinsonizm were applied respectively to both group of patients. The results were evaluated using statistical measures such as "chi square" "t-test" "lineer conelation". No statistically significant differences were found between the two groups of patients concering amount of antipsychotic & anticholinergic medication, positive psychotic .symptoms & degree of akinezia. In the patients not having depressive mood the degree of affective flattening was significantly higher and there was a negative correlation between depressive mood and affective flattening. Patients having depressive mood had more negative symptoms such as avolition, apathy and anhedonia. Those patients with depressive mood had significantly higher points (scores) m psychic anxiety, thoughts of suicide and score for HAM-D was above threshold in this group The results of this study were discussed and compared with the results of other studies.

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