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Yıl:2020; Cilt: 7; Sayı: 1>> Özet
TAM METİN
Türk Uyku Tıbbı Dergisi; 2020;7(1):5-9
Obstüktif Uyku Apneli ve Eşlik Eden Hipertansiyonlu ve Diabetes Mellituslu Hastalarda Ortalama Trombosit Hacmi
AA Geçkil, ÇF Koca
Malatya Eğitim ve Araştırma Hastanesi, Malatya
Amaç: Obstrüktif Uyku Apne sendromu (OUAS) özellikle orta yaş erişkinleri etkileyen yaygın bir hastalıktır. Artmış platelet aktivasyon ve agregasyonu ile kardiyovasküler komplikasyonlar arasında yakın bir ilişki mevcuttur. Ortalama trombosit hacmi, platelet aktivasyonunun bir belirtecidir. OUAS’nin platelet aktivasyonu üzerine etkisi tam olarak anlaşılamamış bir konudur. Gereç ve Yöntem: Bu çalışmaya dahil edilen 192 hasta polisomnografi ile retrospektif olarak incelendi. Apne-hipopne indeksi (AHİ) beşin üzerinde olması OUAS olarak kabul edildi. AHİ beşin altında olanlar kontrol grubu olarak kararlaştırıldı. OUAS grubu apne-hipopne değerine göre üç gruba ayrıldı. AHİ 5-15 arası olanlar hafif, 15-30 arası olanlar orta ve 30 üzeri olanlar ağır grup olarak ayrıldı. Kontrol grubu 28 hastadan (%14,6), hafif obstrüktif uyku apne grubu 31 hastadan (%16,1), orta obstrüktif uyku apne grubu 42 hastadan (%21,9) ve ağır obstrüktif uyku apne grubu 91 hastadan (%47,6) oluşuyordu. Hastaların medikal ve uyku hikayeleri, demografik verileri, kardiyovasküler ve metabolik hikayesi, ilaç kullanımı retrospektif olarak incelendi. Laboratuar incelemesi rutin kan değerlendirmesinden oluşuyordu. Hipertansiyon ve diabetes mellitus hikayesi de ayrıca araştırıldı. Bulgular: Gruplar arasında Desatürasyon indeksi, Vücut Kitle indeksi, AHİ, minimum oksijen satürasyonu ve arousal arasında anlamlı fark mevcuttu (p
Mean Platelet Volume in Patients With Obstructive Sleep Apnea Syndrome and Concurrent Hypertension and Diabetes Mellitus
Objective: Obstructive Sleep Apnea syndrome (OSAS) is a common disorder affecting especially middle-aged adults. Elevated platelet activation and aggregation have a close relationship with cardiovascular complications. Mean platelet volume (MPV) is a marker of platelet activation. The influence of OSAS on platelet activation is not fully understood subject. Materials and Methods: One hundred ninety-two patients who were included in this study examined retrospectively with polysomnography. The Apnea-hypopnea index (AHI) above five was accepted as OSAS. The AHI under five was decided as control group. The OSAS group was categorized into three groups according to AHI values. Patients whose AHI was 5-15 decided as mild, 15-30 as moderate, and above 30 was severe group. The control group consist of 28 patients (14.6%), mild OSAS group consist of 31 patients (16.1%), moderate OSAS group consist of 42 patients (21.9%), and severe OSAS group consist of 91 patients (47.6%). The medical and sleep histories, demographic data, cardiovascular and metabolic histories, drug use of the patients were retrospectively examined. Laboratory analyze consisted of a routine blood evaluation. Hypertension and diabetes mellitus history also investigated. Results: There were significant differences between the groups in desaturation index, Body Mass index, AHI, minimum oxygen saturation, and arousal (p

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