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Yıl:2019; Cilt: 56; Sayı: 2>> Özet
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Nöropsikiyatri Arşivi; 2019;56(2):133-138
Yaşlılık Dönemi Depresyonunda Apatinin Depresif Belirti Şiddeti ve Bilişsel İşlevlerle İlişkisi
GS Varma, C Bingöl , OZ Topak, Y Enli, O Özdel
Pamukkale Üniversitesi , Pamukkale
Amaç: Primer motivasyon kaybı olarak adlandırılan apati yaşlılık dönemi depresyonunda erişkinlik dönemine göre daha sık izlenmektedir. Apatinin depresif belirti şiddeti ve bilişsel işlevlerle ilişkili olduğu, apati varlığının nörobilişsel bozulma açısından yordayıcı olabileceği ileri sürülmektedir. Bu çalışmada, yaşlılık dönemi depresyonunda apati düzeyleri ile depresif belirti şiddeti ve bilişsel işlevler arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntem: Çalışma, 60 yaş ve üzerinde majör depresif bozukluk (MDB) tanısı konulan 40 hasta ve 40 sağlıklı kontrol ile gerçekleştirilmiştir. Katılımcılara sosyodemografik veri formu, yapılandırılmış psikiyatrik görüşme (SCID-I), Hamilton Depresyon Değerlendirme Ölçeği (HAM-D), Hamilton Anksiyete Değerlendirme Ölçeği (HAM-A), MontgomeryAsberg Depresyon Değerlendirme Ölçeği (MADRS), Standardize Mini Mental Test (SMMT), Montreal Bilişsel Değerlendirme Ölçeği (MoCA), Apati Değerlendirme Ölçeği (ADÖ) ve Sheehan Yeti Yitimi Ölçeği (SYYÖ) uygulanmıştır. Bulgular: Çalışmamızda, yaşlı MDB grubunda HAM-D, HAM-A, MADRS ve ADÖ ölçek puanları sağlıklı kontrol grubuna göre yüksek bulunmuştur. MDB grubunda ADÖ puanları ile depresif belirti şiddeti arasında pozitif korelasyon, ADÖ puanları ile bilişsel işlevler arasında negatif yönde korelasyon tespit edilmiştir. MDB grubunda SMMT ve MoCA puanları sağlıklı kontrol grubuna göre düşük bulunmuştur. Yaşlı MDB grubunda özellikle yönelim, görsel/mekansal işlevler, bellek ve lisan alanlarında düşük performans gözlenmiştir. MDB grubunda işlevselliğin kontrol grubuna göre düşük olduğu, apati düzeyi arttıkça işlevselliğin azaldığı tespit edilmiştir. Sonuç: Sonuçlarımız, yaşlılık dönemi depresyonunda apati düzeylerinin sağlıklı kontrol grubuna göre yüksek olduğunu göstermektedir. Yaşlılık döneminde majör depresif bozuklukta bilişsel işlevler olumsuz olarak etkilenmekte, apati düzeyi ile depresif belirti şiddeti, bilişsel işlevlerdeki ve işlevsellikteki bozulma ilişkili görünmektedir.
Relationship of Apathy with Depressive Symptom Severity and Cognitive Functions in Geriatric Depression
Introduction: Apathy which is known as loss of primary motivation is observed more frequently in elderly depression in comparison with younger adults. It is put forth that apathy is related with depressive symptom severity and cognitive functions, that the existence of apathy may be a predictor of neurocognitive impairment. The objective of this study was to examine the apathy levels in elderly patients with major depression as well as the relationship between depressive symptom severity and cognitive functions. Methods: The study was carried out with 40 major depressive disorder patients (MDD) aged 60 and above, 40 healthy controls aged 60 and above. Sociodemographic data form, structured psychiatric interview (SCID-I), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Montgomery-Asberg Depression Rating Scale (MADRS), Standardized Mini Mental State Examination (SMMSE). Montreal Cognitive Assessment Scale (MoCA), Apathy Evaluation Scale (AES) and Sheehan Disability Scale (SDS) were applied to the participants. Results: In our study, HAM-D, HAM-A and MADRS scale scores of MDD group was determined to be higher in comparison with those of the healthy control group. A positive correlation was determined in the MDD groups between the AES scores and depressive symptom severity, whereas a negative correlation was determined between the AES scores and cognitive functions. The SMMSE and MoCA scores of the geriatric MDD group were determined to be lower in comparison with healthy control group. Low performance was observed in the geriatric MDD group especially in the fields of orientation, visual/spatial functions, memory and language. Functionality was found to be lower in MDB group than in the control group, and functionality decreased as the level of apathy increased. Conclusion: Our results indicate that the apathy levels in geriatric depression are higher in comparison with the control group. Cognitive functions are affected adversely in geriatric patients in major depressive disorder, depressive symptom severity, impairment in cognitive functions and functionality are observed to be related with apathy level.

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