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Yıl:2005; Cilt: 16; Sayı: 4>> Özet
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Türk Psikiyatri Dergisi; 2005;16(4):229-236
Bipolar Bozukluğu Olan Hastaların Birinci Derece Akrabalarında Psikopatoloji ve Kişilik Örüntüleri
AS Yıldırım, M Çelik, E Kabakçı, A Uluşahin
Hacettepe Üniv. Tıp Fakültesi Psikiyatri ABD
Amaç: Bu kesitsel çalışmada bipolar bozukluk için yüksek risk taşıyan bir grubun psikopatoloji ve kişilik örüntülerinin bir kontrol grubu ile karşılaştırılması amaçlanmıştır. Yüksek riskli grup olarak bipolar bozukluğu olan hastaların birinci derece yakınları alınmıştır.

Yöntem: Çalışma grubu olarak bipolar I bozukluğu olan 54 hastanın 95 birinci derece yakını, kontrol grubu olarak ise herhangi bir psikiyatrik rahatsızlığı olmayan 54 bireyin 93 birinci derece yakını alınmıştır. Kontroller ile bipolar bozukluk hastaları yaş, cinsiyet ve eğitim durumu bakımından eşleştirilmiştir. Hem hasta ve kontrollerdeki psikiyatrik durumun belirlenmesinde hem de hasta ve kontrol yakınlarındaki psikopatolojinin değerlendirilmesinde SADS-L (Duygudurum Bozuklukları ve Şizofreni Ölçeği Yaşam Boyu Versiyonu; Schedule for Affective Disorders and Schizophrenia-Lifetime Version) kullanılmıştır. Hasta ve kontrol yakını gruplarının MMPI-2 profilleri de karşılaştırılmıştır.

Bulgular: SADS-L ile hipomani, minör depresyon ve şizotipal kişilik tanıları bipolar bozukluğu olan hastaların yakınlarında kontrol grubunun yakınlarına göre anlamlı düzeyde daha sık konmuştur. Hem bipolar bozukluk hastalarının hem de kontrollerin yakınlarında MMPI-2 profilleri normal sınırlar içinde bulunurken hasta yakınlarının psikopatolojiyi açığa vurmada daha savunucu oldukları görülmüştür.

Sonuç: Bipolar I bozukluğu olan hastaların birinci derece yakınlarında minör ruhsal hastalıklar (hipomani, minör depresyon) daha sık görülürken; MMPI-2 değerlendirmesi ile bipolar I bozukluk açışından yüksek riskli gruba özgü bir kişilik profili saptanmamıştır.
Psychopathology and Personality Patterns in the First-Degree Relatives of Bipolar Patients
Objective: This is a cross-sectional study designed to assess psychopathology and personality patterns in a group of high-risk subjects for bipolar disorder compared to a control group. As high-risk subjects first-degree relatives of bipolar patients were selected.

Method: Ninety-five first-degree relatives of 54 bipolar patients and 93 first-degree relatives of 54 subjects without any psychiatric disorder were recruited in the study. Control subjects were matched to bipolar patients according to age, gender and educational status. SADS-L (Schedule for Affective Disorders and Schizophrenia-Lifetime Version) was used both to ascertain the psychiatric status of the patient and control subjects, and to evaluate the psychopathology in probands’ and controls’ relatives. MMPI-2 (Minnesota Multiphasic Personality Inventory-2) profiles of relatives of patient and control groups were compared as well.

Results: In the relatives of bipolar patients the SADS-L diagnoses of hypomania, minor depression and schizotypal personality were statistically more prevalent than in the relatives of the control group. MMPI-2 profiles of both relatives of bipolar patients and controls were within “normal” range, whereas relatives of patients were more defensive in disclosing psychopathology. Any specific profile characteristic for relatives of bipolar patients could not be described.

Conclusion: Minor mental disorders were more prevalent in the relatives of bipolar patients group. A personality pattern spesific to high risk group for bipolar disorder couldn’t be detected.

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