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Yıl:1999; Cilt: 36; Sayı: 2>> Özet
Nöropsikiyatri Arşivi; 1999;36(2):115-122
Demansta tedavi yaklaşımları
E Saka, T Dalkara, M Emre
Hacettepe Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara
Demansta tedavi yaklaşımları: Demansm en sık ne­denleri Alzheimer Hastalığı ikinci olarak da vasküler demanslardır. Her iki hastalık için de halen kesin bir tedavi olmamakla birlikte, değişik farmakolojik te­davi stratejileri araştırılmaktadır. Alzheimer Hastalı­ğının semptomatik tedavisinde şu an en uygun te­davi seçeneğini kolinerjik tedavi, özellikle kolineste-raz inhibitörleri oluşturmaktadır. Anti-inflamatuvar ajanlar, Östrojen tedavisi, büyüme faktörleri ve ami-loid oluşumunu önleyen ilaçların hastalığın patolo­jik kaskadını kırarak ve hastalığın progresyonunu yavaşlatarak etkili olabileceği umulmaktadır. Alzhe­imer Hastalığı tedavisinde araştırılan bu yöntemlere karşın, vasküler demans tedavisi serebrovasküler hastalığın önlenmesi ile kısıtlıdır. Tüm demanslarda ortak olan tedavi ise destekleyici yaklaşımlarla has­taların yaşam kalitesini yükseltmektir.
Treatment Approaches In Dementia
Alzheimer Disease is the most common cause of de­mentia followed by vascular dementias. Although there is still no restorative treatment for these dise­ases, several pharmacological strategies are under investigation. Cholinergic therapy, particularly cho-linesterase inhibitors, constitutes the best available symptomatic treatment for Alzheimer's Disease. An­ti-inflammatory agents, estrogens, nerve growth fac­tor and drugs that prevent amyloid formation are hoped to influence the pathological processes and slow down the progression of Alzheimer's disease. Therapy of vascular dementia consists mainly of preventing cerebrovascular accidents. Common to management of all dementias is the supportive the­rapy that can significantly improve the quality of li­fe in these patients.

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