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Yıl:2016; Cilt: 17; Sayı: Ek 3>> Özet
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Anadolu Psikiyatri Dergisi; 2016;17(Ek 3):11-13
Haloperidol depo ile gelişen bir nöroleptik malign sendrom olgusu
H Yiğit, T Mutu, ES Örsel, A Erol
Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi, Sakarya
Antipsikotiklerin depo (uzun etkili) formlarının geliştirilmesi kronik seyirli psikotik hastaların tedavi uyumsuzlukları için önemli bir çözüm olmuştur. Çeşitli avantaj ve dezavantajlara sahip olan depo antipsikotiklerin dezavantajlarından biri nöroleptik malign sendrom (NMS) oranlarının oral formlardan daha yüksek olmasıdır. NMS, nadir fakat ölüm ile sonlanabilen, nöroleptik kullanımı sonrası bilinç bulanıklığı, hipertermi, otonomik disfonksiyon ve kas rijiditesi ile karakterize idiyosenkratik bir reaksiyondur. Bu vakada, haldol decanoate adı ile yurtdışında (Avrupa-US) 1986’dan beri kullanılan ancak Türkiye’de yakın zamanda kullanıma giren haloperidol depo kullanıldığı şizofreni hastasında gelişen NMS tablosu anlatılmıştır.
A neuroleptic malignant syndrome case with haloperidol depot
The development of depot antipsychotics are facilitated incompitable patient’s treatment process for in terms of chronic disease course. One of the disadvantages of depot antipsychotics, having various advantages and disadvantages, neuroleptic malignant syndrome (NMS) rate is higher than the oral form. NMS, rare but can be fatal, is an idiosyncratic reaction characterized by confusion, hyperthermia, autonomic dysfunction, muscle rigidity after use of neuroleptics. In this case, a schizophrenia patient used to haloperidol depot, named haldol decanoate in abroad used since1986 (Europe-US) but recently introduced in Turkey, with NMS was reported.

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