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Yıl:2015; Cilt: 22; Sayı: 2>> Özet
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Çocuk ve Gençlik Ruh Sağlığı Dergisi; 2015;22(2):125-129
Bipolar Bozukluğu Olan Bir Ergende Olanzapin Tedavisine Bağlı Masif Serum Kreatin Kinaz Yüksekliği
C Tanıdır, T Eseroğlu, S Bozbey, H Adaletli, ÖŞ Üneri
Prof.Dr.Mazhar Osman Bakırköy Ruh Ve Sinir Hastalıkları E.A.H, İstanbul
Yazında atipik antipsikotiklere bağlı serum kreatin kinaz (CK) değerlerinin yükseldiğini gösteren olgu sunumları mevcuttur. Bu yazıda kısa süreli olanzapin tedavisi sonrası serum CK değeri 32440 U/L düzeyine (normal değerler: 30-200 U/L) çıkan bipolar bozukluk tanılı ergen bir olgunun klinik seyrinin, ayırıcı tanısının ve CK yükselmesinin mekanizmasının tartışılması amaçlanmıştır. Antispikotiklere bağlı CK yükselmesinin mekanizması net değildir ancak bu gibi olgularla karşılaşıldığında, olabilecek diğer tıbbi sebepler dışlanmışsa, ilacın kesilerek belirli aralıklarla kan değerlerinin izlenmesi yeterli gibi görünmektedir.
Massive Serum Creatine Kinase Elevation due to Olanzapine Treatment in an Adolescent with Bipolar Disorder
There are case reports that indicate creatine kinase (CK) elevation due to atypical antipsychotic treatment in literature. In this article we aimed to disscuss the clinical course, differential diagnosis and the mechanism of CK elevation in an adolescent with bipolar disorder whose serum CK levels increased to 32440 U/L (normal range: 30-200 U/L) after short-term olanzapine treatment. The mechanism of CK elevation due to antipsychotic use is not clear; however currently, when compared to cases like this presented one, it seems adequate to stop the antipsychotic medication and monitor serum CK levels periodically if other possible medical causes are excluded.

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