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Yıl:2014; Cilt: 1; Sayı: 2>> Özet
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Türk Uyku Tıbbı Dergisi; 2014;1(2):46-50
Sistemik Hastalığı Olmayan Obstrüktif Uyku Apne Sendromlu Hastalarda Ani Kardiyak Ölüm Riskinde Kardiyak Repolarizasyon İndeksinin Rolü
K Aslan, DY Şahin, T Demir, A Evlice, G Şeydaoğulları
Çukurova Üniversitesi, Adana
Giriş: Obstrüktif uyku apne sendromlu (OUAS) hastalarda ani kardiyak ölüm riskinin yüksek olduğu bilinmektedir. Bu çalışmada hipertansiyon (HT), diyabet (DM), tiroid, kalp hastalığı, elektrolit bozukluğu gibi kronik sistemik hastalığı olmayan hastalarda kardiyak repolarizasyon indeksine bakılarak ani kardiyak ölüm ilişkisi irdelenmek istenmiştir. Gereç ve Yöntem: Çalışmaya, Ocak 2008- Ocak 2010 tarihleri arasında, horlama, tanıklı apne yakınmaları gereği OUAS ön tanı ile polisomnografik (PSG) inceleme yapılan yaş ortalaması 44,45±10,1 (21-75) olan 134 erkek, 36 kadın toplam 170 hasta dahil edilmiştir. PSG öncesi 12 kanallı elektrokardiyografik kayıtları yapılmış ve QT minimum, QT maksimum ve QT dispersiyonları hesaplanmıştır. Bulgular: Hastalar apne-hipopne indeksine (AHİ) göre dört gruba ayrılmıştır; AHİ ?5, 5< AHİ ?15, 15< AHİ <30, ve AHİ ?30. Ortalama QTD 3,8±2 (0,40-9,7) msn, normal olan grupta (AHİ ?5) 3,5±1,8 (0,6-8,9) msn, ağır olan grupta (AHİ ?30) ise 4,5±1,9 (0,4-9,7) msn olarak belirlenmiştir (p=0,010). Hastalarda AHİ arttıkça, QTD artmış olarak belirlenmiştir. Sonuç: Kronik sistemik hastalığı olmayan OUAS hastalarının QT uzaması nedeni ile ani kardiyak ölüm riskleri vardır.
The Role of Cardiac Repolarization Index for Sudden Cardiac Death Risk in Patientswith Obstructive Sleep Apnea Syndrome without any Systemic Disesae
Introduction: Obstructive sleep apnea syndrome (OSAS) is associated with sudden cardiac death (SCD). In this study we aimed to evaluate the ventricular recovery time in OSAS patients without chronic systemic diseases, such as hypertension, diabetes, thyroid dysfunction, electrolyte imbalance, cardiac disease and the relationship of OSAS with SCD. Materials and Methods: In the study, between January 2008-January 2010, we analyzed 170 patientswith a mean age of 44.45±10.1 (21-75) years, who were clinically suspected of having OSAS. Following overnight polysomnography (PSG), 12 lead surface electrocardiogram (ECG), recordings were perforned and QT minimum, QT maximum and QT dispersion were computed from ECG. Results: The patients were divided into to the following 4 groups; AHI (apnea-hypopnea index) ?5, 5< AHI ?15, 15< AHI <30, and AHI ?30. The mean QTD was 3.8±2 (0.40-9.7) msn in all patients and 3.5±1.8 (0.6-8.9) msn in normal group (AHI ?5), and 4.5±1.9 (0.4-9.7) msn in severe group (AHI ?30). It is shown that QTD increases significanty when AHI rises. Discussion: We showed that the patients with OSAS without chronic systemic disorder have higher SCD risks due to increased QT dispersion.

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