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Yıl:2014; Cilt: 1; Sayı: 2>> Özet
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Türk Uyku Tıbbı Dergisi; 2014;1(2):38-42
Çocuk Yaş Grubunda Obstrüktif Uyku Apne Sendromu
G Benbir, D Karadeniz
İstanbul Üniversitesi, İstanbul
Obstrüktif uyku apne sendromu (OUAS), çocukluk ve erişkin olmak üzere iki gruptan oluşmaktadır. Çocuklarda tam oranı bilinmemektedir; erkek çocuklarda daha sık olmak üzere genel görülme sıklığı yaklaşık %1 olarak tahmin edilmektedir. Predispozan faktörler arasında, ileri yaş önemli bir risk faktörü olmakla birlikte, pediyatrik yaş grubunda erkek cinsiyet, obezite (85. yüzdelik dilim üstü; vücut kütle indeksi (VKİ) >25 kg/m2), hipotiroidi ya da diğer endokrin bozukluklar, kraniyo-fasiyal anatomik bozukluk ve birinci derecede akrabalarda OUAS öyküsü (2-8 kat) olması yer almaktadır. Huzursuz uyku, uykuda çok sık hareket etme ve özellikle boyun ve göğüs bölgesinde olmak üzere terleme hastalarının yaklaşık yarısında mevcuttur. Noktüri pediyatrik yaş grubunda enürezis noktürna şeklinde kendini gösterebilir. Gastro-özefajeal reflü, gece ağız açıklığı ve ağız suyun akması da çocuk yaş grubu OUAS hastalarında sık karşılaşılan şikayetlerdir. OUAS çocuk yaş grubunda da kardiyovasküler hastalıklar için risk oluşturmaktadır. OUAS’lı çocuklarda kan basıncı, sempatik sinir sistem aktivitesi/parasempatik sinir sistem aktivitesi oranı ve noradrenalin düzeyleri anlamlı olarak yüksek saptanmıştır. Uyku apnesinin küçük yaşlarda dahi noktürnal sempatik aktivasyon ile seyrettiği ve buna bağlı olarak ikincil kardiyovasküler komplikasyonlara yol açabileceği bilinmelidir. Cerrahi tedavi erişkinlere kıyasla çocuklarda çok daha ön planda düşünülmekte ve pozitif havayolu basıncı tedavisi ile birlikte birincil tedavi basamağını oluşturmaktadır.
Obstructive Sleep Apnea Syndrome in Pediatric Age Group
Obstructive sleep apnea syndrome (OSAS) is divided into two categories; in adults and in children. Although its exact incidence in pediatric age group is not well-known, it is suggested as occurring in approximately 1% of young children. Although advanced age is a very important risk factor for OSAS, some amongst the predisposing factors for OSAS in children are male gender, obesity (above 85th percentile; body mass index >25 kg/m2), hypothyroidism or other endocrine disorders, craniofacial abnormalities and the family history of OSAS in-first degree relatives (2-8 times). Nonrestorative sleep, frequent body movements during sleep and sweating especially in the neck and chest area, are the symptoms observed in almost half of the patients. Nocturia may manifest itself as nocturnal enuresis in the pediatric age group. Gastroesophageal reflux and open mouth saliva drooling during sleep are also commonly encountered in children with OSAS. OSAS is also an important risk factor for cardiovascular diseases in the pediatric age group. Increased blood pressure, sympathetic and parasympathetic nervous system activities and noradrenalin levels are reported to be common in children with OSAS. It should be noted by the physicians that even in youngl age, sleep apnea is associated with increased nocturnal sympathetic activity, and therefore cause of secondary cardiovascular complications. Surgical intervention is more commonly suggested in the treatment of OSAS in pediatric age group and constitutes first-line therapy together with positive airway pressure therapy.

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