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Yıl:2014; Cilt: 1; Sayı: 1>> Özet
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Türk Uyku Tıbbı Dergisi; 2014;1(1):28-32
Panik Bozukluğu Hastalarında Uykuda Kalp Hızı Değişkenliği
S Yetkin, A Erdamar, M Yokuşoğlu, F Özgen, H Aydın
Gülhane Askeri Tıp Akademisi, Ankara
Giriş: Çalışmalar genel olarak panik bozukluğunda azalmış vagal tonus ve göreceli olarak artmış hakimiyetin olduğu, azalmış kalp hızı değişkenliğini (KHD) işaret etmektedir. Gündüz çalışmaları panik bozukluğu hastalarında daha tutarlı şekilde düşük kalp hızı değişkenliğini sonucu verirken, uykuda KHD çalışmaları çelişkili sonuçlar vermektedir. Bu nedenle, panik bozukluğu hastalarında polisomnografi kayıtlarını kullanarak kardiyak otonomik işlevin araştırılması amaçlanmıştır. Gereç ve Yöntem: On beş tedavi almayan panik bozukluğu hastası ve 15 yaş ve cinsiyet yönünden eşleştirilmiş normal kontrol grubu ardışık iki gece polisomnografi kaydı ile çalışılmıştır. Analiz için ikinci gece kayıtları alınmıştır. Bulgular: Hastalar düşük uyku etkinliği, artmış uyanıklık sayısı ve uzamış uyku latansı göstermekteydi. Panik bozukluğu ve kontrol grubu arasında zaman ve frekans-alan KHD değişkenleri karşılaştırıldığında istatistiksel olarak anlamlı bir fark elde edilememiştir. Sonuç: Bu sonuç tedavi almayan hastalığın erken dönemindeki panik bozukluğu hastalarında sempatovagal dengenin etkilenmemiş olabileceğini işaret etmektedir.
Heart Rate Variabilty During Sleep in Patients with Panic Disorders
Introduction: Studies generally indicate that panic disorder patients have reduced heart rate variability (HRV), diminished vagal tone and relative sympathetic dominance. Despite a consistent profile of reduced HRV in PD patients during daytime assessments, sleep-based HRV studies have yielded inconsistent results. For this reason, we aimed to investigate cardiac autonomic function in PD patients using polysomnographic records. Materials and Methods: 15 non-medicated PD patients and 15 ageand sex-matched normal controls were studied on polysomnography on two consecutive nights. Data were extracted from the second night for analysis. Results: Patients showed poor sleep efficiency, increased the number of the awakenings, and longer sleep latency than controls. Comparison of time domain and frequency domain HRV parameters between PD patients and control subjects revealed that there were no statistically significant differences. Discussion: The results indicate that the sympathovagal balance might not be influenced in drug-free patients with panic disorder in the early stage of illness.

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