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Yıl:2015; Cilt: 2; Sayı: 1>> Özet
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Türk Uyku Tıbbı Dergisi; 2015;2(1):7-10
Elektrokonvülsif Terapi için Sevk Edilen Tedaviye Dirençli Depresyonlu Hasta Örneğinde Uyku Apne
CT Fitgerald, E Hiett, DJ Buysee, N Altıntaş, G Aikman, H Fırat
University of Pittsburgh, USA
Amaç: Genellikle depresyon ve uyku apne (UA) semptomları örtüşür. Hastaların geniş kapsamlı öyküleri alınmadığı taktirde, tedavi dirençli depresyon (TDD) nedeni ile elektrokonvülsif terapiye (EKT) giden hastalardaki depresyonun uyku apnenin komplikasyonu olabilir. Gereç ve Yöntem: Orta Arkansas Veteran Sağlık Sistemi’ne 2008’den 2011’e (N=118) TDD nedeni ile EKT için başvuran hastaların retrospektif dosyalarının taraması ile yapılmıştır. Hastalar, bilinen uyku apneli hastalar (tanısı konmuş ve hasta dosyasına işlenmiş), yüksek riskli uyku apneli hastalar (uyku apne bir hekim tarafından şüphelenmiş ve dosyalarına işlenmiş) ya da bilinmeyen/düşük riskli uyku apneli hastalar (negatif polisomnografi) olarak kategorize edildiler. Bulgular: Hastaların yaş ortalaması 54,5±12 yıl, ortalama Vücut kitle indeksleri (VKİ) 30,3±7,3 kg/m2 idi. Hastaların %27’sinin test ile gösterilmiş uyku apnesi ve %9’unun şiddetli uyku apne şüphesi olmak üzere toplam %36’sının uyku apnesi vardı. Bilinen uyku apnesi olanlarda, hipertansiyon (9,4 CI 3-29,5) VKİ?30 kg/m2 (5,4 CI 2,2-13,5), ve hiperlipidemi (4,2 CI 1,6-11,4) olasılığı daha yüksekti. Uyku apne, diabetes mellitus (2,2 CI 0,8-5,6) ağrı) şikayetleri (2,4 CI 0,9-5,9), ya da baş ağrısı (1,5 CI 0,6-3,8) ile ilişkili değildi. Sonuç: Uyku apne tanısı EKT için sevk TDD’li hastalarda düşünülmelidir. VKİ?30 kg/m2, hipertansiyon varlığı, ve hiperlipidemi sıklığı, uyku apneli hastalarda daha yüksektir ve bu popülasyondaki kişilerde hastalık şüphesi akla gelmelidir.
Sleep Apnea in a Sample of Patients with Treatment Resistant Depression Referred for ElectroconvulsiveTherapy
Objective: Symptoms of sleep apnea (SA) often overlap with symptoms of depression. Without extensive exploration of a patient’s history it is possible that SA could complicate depression leading to treatment resistant depression (TRD) which is then referred for electroconvulsive therapy (ECT). To date no study has reported on prevalence of SA within this population. Materials and Methods: We conducted a retrospective chart review of patients referred for ECT for TRD from 2008 to 2011 (N=118) at the Central Arkansas Veteran’s Healthcare System. Patients were placed into categories of known SA (diagnosed with polysomnography and recorded on chart), high risk SA (suspected SA documented in the chart by a physician), or unknown/low risk SA (negative polysmonography). Results: Average age was 54.5±12 years. Average body mass index (BMI) was 30.3±7.3 kg/m2. 36% had either known SA (27%) or were at high risk of having SA (9%). Those with known SA were more likely to have hypertension (9.4 CI 3-29.5), BMI?30 kg/m2 (5.4 CI 2.2-13.5), and hyperlipidemia (4.2 CI 1.6-11.4). Known SA was not significantly associated with diabetes mellitus (2.2 CI 0.8-5.6), complaints of pain (2.4 CI 0.9-5.9), or headache (1.5 CI 0.6-3.8). Conclusion: A diagnosis of SA should be considered in patients referred for ECT for TRD. BMI?30 kg/m2, presence of hypertension, and hyperlipidemia are more likely in patients with SA and should raise suspicion of the disorder in patients within this population.

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