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Yıl:2015; Cilt: 26; Sayı: 2>> Özet
TAM METİN
Türk Psikiyatri Dergisi; 2015;26(2):142-145
Psikotik Bozukluk ve Sheehan Sendromu: Etiyoloji mi, Eştanı mı?
B Tıkır, E Göka, MÇ Aydemir, Ş Gürkan
Ankara Numune Eğitim ve Araştırma Hastanesi, Ankara
Sheehan sendromu (postpartum hipopituitarizm), doğum esnasında veya doğum sonrası fazla miktarda kanama nedeniyle hipofiz bezinin nekroze olması ile karakterize bir sendromdur. Agalaktore, amenore, hipotiroidi veya hipoglisemi belirti ve bulguları ile tanınabildiği gibi bazen nadir de olsa psikoz gibi psikiyatrik klinik tablolar ile ortaya çıkabilir. Bu yazıda, psikotik bozukluk ile başvuran ve aynı zamanda Sheehan sendromu tanısı konulan bir olgu sunulmuştur. 44 yaşında, kadın hasta bir haftadır olan içe kapanma, sinirlilik, uykusuzluk, kimsenin duymadığı -kendisine hakaret eden- sesler duyma, çevresindekilerden zarar göreceği ve eşi tarafından aldatıldığı düşünceleri ile başvurdu. Hastaya psikotik bozukluk tanısı ile olanzapin 20 mg/gün tedavisi başlandı. Ayrıca hipopituitarizm bulguları olan hastaya hormon tetkikleri ve hipofiz MRG’si sonucunda Sheehan sendromu tanısı konması üzerine tedavisine prednizolon ve tiroksin eklendi. Tedavi sonrası bir ay içinde yakınmaları geçen hastanın antipsikotik tedavisi 4. ayın sonunda kesilerek tedaviye prednizolon ve tiroksin ile devam edildi. Yapılan çalışmalarda psikotik belirtilerin etiyolojisinde endokrin sistem ve bağışıklık sistemi bozuklukları suçlanmaktadır. Bu makalede, aynı zamanda psikotik bozukluğu olan 24 yıl geç tanı konmuş Sheehan sendromu olgusu takip ve tedavi süreci ile etiyolojik açıdan tartışılmaktadır.
Psychotic Disorder and Sheehan’s Syndrome: Etiology or Comorbidity?: A Case Report
Sheehan’s Syndrome -also called postpartum hypopituitarism- is a syndrome which characterized by lots of bleeding during or after delivery and necrosis of pituitary gland due to hypovolemic shock. It appears with not only agalactorrhea, amenorrhea, hypoythyroidism and hypoglycemia but also psychiatric disorders like psychosis. In this study, we reported a case presented with psychotic disorder and diagnosed as Sheehan’s Syndrome at the same time. 44 year-old, female patient, married. She was admitted for withdrawal, irritability, insomnia, hearing voices -especially insult her- thoughts about that her husband was cheating on her and people would do evil. She was diagnosed as psychotic disorder and she was treated with olanzapine 20 mg/day. She had hypopituitarism symptoms so hormone tests and cranial MRI are done. Sheehan’s syndrome was also diagnosed and prednisolone and tyroxine were added to the treatment. Her symptoms were disappeared one months later Olanzapine was stopped after 4 months and her treatment continued with prednisolone and tyroxine. Studies about etiology of psychotic symptoms refer to endocrine and autoimmune systems. In this study, we discussed a case that diagnosed as psychotic disorder and Sheehan’s Syndrome -diagnosed 24 years later and etiological aspect with the follow-up period and treatment.

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