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Yıl:2012; Cilt: 22; Sayı: 4>> Özet
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Klinik Psikofarmakoloji Bülteni; 2012;22(4):293-296
Monoamin oksidaz inhibitörleri ve nöroprotektif mekanizmalar
GB Baker, D Matveychuk, EM MacKenzie, SM Dursun, DD Mousseau
1Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
Son yıllarda monoamin oksidaz inhibitörleri uzerinde ki ilgi de bir canlanma olmuştur, bunun başlıca nedeni in vivo ve in vitro çeşitli toksik durumlarda bu ilaçların bazılarının nöroprotektif ve / veya sinir kurtarıcı (neurorescue) özellikler göstermeleridir. Bu, genelde psikiyatrik ilaçların olası nöroprotektif etkilerine artan bir ilgi, glia-nöron etkileşimlerin daha iyi anlaşılmasını ve psikiyatrik ve nörolojik bozuklukların tedavisi için gelecekte yeni ilaçlar geliştirilmesi için önemli ipuçları sağlanması sonuçlarını doğurmuştur. Bu editoryalde bu alanla ilgili bazı çalışmaların kısa özeti sunulmuştur.
Monoamine oxidase inhibitors and neuroprotective mechanisms
There has been a resurgence of interest in recent [year]s in monoamine oxidase inhibitors, primarily because of the demonstrated neuroprotective and/or neurorescue properties of several of these drugs in a variety of toxic situations in vivo and in vitro. The consequence has been an increased interest in possible neuroprotective effects of psychiatric drugs in general, an improved understanding of glia-neuron interactions, and the provision of important clues to development of future drugs for treating psychiatric and neurological disorders. A brief overview of some relevant studies in this area is provided in this editorial.

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